Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth

Abstract Sphingosine kinases (SphK), including SphK1 and SphK2, are important enzymes promoting progression of prostate cancer.SKI-178 is a novel and highly potent SphK1/2 dual inhibitor.We here tested the potential anti-prostate cancer cell activity of SKI-178.Bioinformatics analyses and results from local tissues demonstrated that that both SphK1

read more